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Methods based on frequentist statistical inference are also less than ideal in the context of epistasis.
Table 3 compares the pharmacokinetic parameters and demographics in patients with and without hearing loss, based on frequentist statistical inferences.
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However, all these articles ignored this prior knowledge because they were based on frequentist statistics that test the null hypothesis that parameters are equal to zero.
Among the five heterogeneous variances MTC model, the informed variances model based on frequentist approximate distributions produced variance estimates closest to the frequentist ones and had the posterior variance distributions with the highest precision.
Patients were classified into two response groups based on frequentist mixture analysis using the total Alda scale score.
Patients were classified into good responders and moderate/poor responders as defined based on frequentist mixture analysis using the total Alda scale score.
Based on frequentist mixture analysis of the total score, 27 (33.8%) and 53 (66.2%) patients were classified into the good response and moderate/poor response groups, respectively.
The informed variance model based on frequentist approximate distributions yielded the best model fit according to the DIC.
In this example, a number of reasons suggest the informed variances model based on frequentist approximate variance distributions is the more optimal choice.
While the considered clinical trials designs are based on frequentist hypothesis tests, the evaluation of the expected utility of the trials follows a Bayesian approach, assuming a prior distribution on the efficacy parameters.
In complex cases, the function might not be numerically tractable, in which case one would use numerical integration methods based on Bayesian or frequentist statistical methods15.
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