Sentence examples for almost complete blockade from inspiring English sources

Both genotypes showed a downward trend in the Stat1 response to IFNα as the mice aged, but the lpr mice showed an almost complete blockade of this pathway in all cell types starting at 10 weeks of age (Fig. 3A).

RNAi experiments performed in INS-1E cells revealed that silencing of RalGDS lead to an almost complete blockade of RalA activation, suggesting that in β-cells the elevation of [Ca2+]i stimulates the GTPase mainly via the second mechanism.

In this regard, our results reveal that changes in Math6 mRNA levels affect the ability of Neurog3 to activate its own gene; as overexpression of Math6 leads to an almost complete blockade of this positive autoregulatory loop, while it does not affect Neurog3 gene activation by other regulators such as Mash1 (L.Sanchez, R.Gasa unpublished observations).

An inhibition of 50% was achieved after 4 5 h treatment, and an almost complete blockade of productive infection was achieved when DMSO is present for the first 8 h after adsorption.

Higher doses (100 nM) of endoxifen and 4HT, as well as a low dose (10 nM) of ICI, resulted in almost complete blockade of estrogen-induced proliferation in ERβ1-expressing cells but not in parental cells expressing only ERα.

Nanobody-based TRNT in mice-bearing small established HER2pos tumors (tumor volume of 20 – 30 mm) led to an almost complete blockade of tumor growth and a significant difference in event-free survival between the treated and the control groups.

China was almost completely blockaded.

Pharmacological blockade of NF-κB produced almost complete inhibition of CpG DNA-stimulated TF protein expression and activity.

During the Berlin Blockade, the long-distance traffic came to an almost complete halt.

As for the induction of Notch signaling by DLL4 in co-culture, a number of genes, such as P2RY11, MOB4, FAM183A and PRSS22, showed robust upregulation by DLL4 and an almost complete downregulation by DAPT (Fig.  3c) but, at the genome-wide level, the DAPT blockade of the immobilized DLL4 was incomplete, although more effective than in the co-culture setting (PCA; Fig.  3d).

Since it is possible to block the estrogen receptor pathway almost completely with letrozole, the next step should be to target those growth pathways that may be up-regulated by complete blockade of the estrogen-dependent pathways.