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In contrast, cancer cells later adapt to develop a resistance to TGF-β1-mediated growth inhibition by increasing expression of TGF-β1 antagonist, mutating the TGF-β1 receptor or inactivating the SMAD4 gene.
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This puts a premium on the system being flexible enough to adapt to developing thinking, whilst being sufficiently robust to maintain the key elements.
RAPDs were also adapted to develop different molecular marker approaches to screen the samples quickly and cheaply.
Organoids can also be adapted to develop in vitro models of several types of malignancies from intestine/colon, stomach, pancreas, prostate, brain and lung (Schweiger and Jensen, 2016).
This chapter reviews textile-engineering techniques as versatile platform technologies for biomedical applications and how these approaches could be adapted to develop functional, 3D scaffolds for tissue engineering.
Dewey had argued that the scientific method as a method for mediating conflicting opinions by an appeal to consequences could be adapted to develop institutions for the peaceful negotiation of differences that had previously led to war.
Essential procedures for HWs in conflict zones were identified, and teaching methods were adapted to develop models that were simple, reproducible, cost effective, and able to facilitate effective learning within the limitations of these challenging environments.
As a result of the CALIPSOneo project, PLM tools were adapted to develop working methods based on collaborative engineering, and particularly to develop the industrial Digital Mock-Up (iDMU).
The fusion constructs may be modified to target other molecules to promote axonal regeneration and the concept may also be adapted to develop gene therapy strategies to treat other disorders.
It describes how the original work of Prof. Kudo with his unit deforming regions has been adapted to develop the simulation tool known as the upper bound elemental technique.
We did not have success with every student but we were able to make difference with the majority and this model was later adapted to develop an all freshman academy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com