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The acute lethal toxicity test was carried out according to 48 h LC50 test (ISO 14669 1999) using Arcatia tonsa.
Acute lethal toxicity was observed following the administration of either 10 microg anti-CD40 MoAb (FGK45) or 0.5 microg of recombinant murine (rm IL-12 that rm IL-12 in 100% morthatty of all mice within 4 to 6 days.
The emerging data on toxicity to fishes suggest that ENMs only show acute lethal toxicity in the mg l−1 range, but sublethal effects at concentrations <1 mg l−1 have been found.
It has low acute lethal toxicity to mammals, birds, and fish: the acute oral LD50 (dose that is lethal in 50% of animals) of imidacloprid in rats is 475 mg/kg and the acute dermal LD50 exceeds 5000 mg/kg.
There was no difference in acute lethal toxicity between embryo and adult medaka.
These results indicated that rmRetn might be a protective agent against the acute lethal toxicity of chemotherapy for mice.
Similar(52)
The toxicity results demonstrated that the acute lethal concentration of NDEA causing 50% mortality in 96 h (96-h LC50) was 210.4 mg/L, and NDEA was more likely to be accumulated in kidney, followed by liver and gill.
Pulmonary dissection is an acute, lethal disease to patients.
The lethal toxicity of the as-prepared BoNTs was determined according to the previous method [28].
Indeed, lethal toxicity to bacterial lipopolysaccharide varies almost 10,000-fold in different species [38].
The data of MLA indicated that the lethal toxicity were 1.3 × 107 median lethal dose (LD50)/mL for BoNT/A and 1 × 106 LD50/mL for BoNT/B (Table. 1).
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