a systemic alteration

USAGE SUMMARY

The phrase "a systemic alteration" is correct and usable in written English.
It can be used when discussing changes that affect an entire system or organization, often in contexts like healthcare, economics, or social structures. Example: "The new policy introduced a systemic alteration in the way resources are allocated across departments."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

5 human-written examples

Because the effects of TGF-β on osteoblast and osteoclast function are dynamic, dose-dependent, and specific for each cell type and stage of differentiation [4], [12] [14], prior studies do not indicate how the cell types present in mature bone will respond to a systemic alteration in TGF-β signaling.

Plosone

Our results do not suggest a systemic alteration of the CCR3/CCL11 receptor/ligand complex in patients with neovascular AMD.

BMC Ophthalmology

Malnutrition is a systemic alteration, potentially reversible, caused by imbalance between the nutrient intake and energy requirements [ 1].

BMC Gastroenterology

The observation that Mao-B activities in brain and platelets correlate positively with ageing [ 107] has led researchers to suggest a systemic alteration of this potential neurological biomarker.

Acta neuropathologica communications

Nevertheless, perturbed expression of numerous PPAR target genes controlling fatty acid oxidization and transport, cholesterol metabolism, adipocyte differentiation, and gluconeogenesis suggested a systemic alteration of lipid homeostasis.

BMC Genomics

Human-verified similar examples from authoritative sources

Similar Expressions

55 human-written examples

We verified that local treatment with TBHsp70 had a local effect, though it still remains to be determined if any systemic alterations were induced.

Plosone

Illness, which presents with varying severity, stability and duration, represents a systemic functional alteration in the human organism.

Critical Care

The present work supports the idea of a systemic genetic alteration in celiac patients that leads to the constitutive and anomalous activation of the NFκB route, a hallmark of the disease.

Human Molecular Genetics

Targeted modification of tumor microenvironment using LPH NP may allow for tumor cell-specific intervention without the adverse effects and complications from the systemic alteration.

ACS Nano

Bone remodeling becomes perturbed in a variety of pathologic conditions that affect the skeleton, including post-menopausal osteoporosis and rheumatoid arthritis, in which there is local and/or systemic alteration in the levels of hormones or proinflammatory cytokines that are known to stimulate or inhibit bone resorption in vitro and in vivo.

Arthritis Research and Therapy

In healthy humans, sustained changes in arterial and arteriolar wall tension occur regularly, not only as a consequence of systemic alterations of arterial pressure, such as in connection with altered level of physical or mental stress, but also due to local pressure changes induced by the gravitoinertial force field.

European Journal of Applied Physiology

Expert writing Tips

Best practice

When using "a systemic alteration", ensure the context clearly indicates the system being affected (e.g., biological system, economic system, organizational system). This provides clarity and avoids ambiguity.

Common error

Avoid using "a systemic alteration" when a simpler term like "change" or "modification" would suffice. Overusing the phrase can make your writing sound unnecessarily complex or pretentious. Opt for simpler language when the systemic nature of the alteration isn't the key point.

Linguistic Context

The phrase "a systemic alteration" functions as a noun phrase, typically serving as a subject complement or object. As Ludwig AI explains, it denotes a change or modification that affects an entire system rather than a localized part. The examples in Ludwig demonstrate its use in scientific contexts.

Expression frequency: Rare

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Academia

0%

Ludwig's WRAP-UP

In summary, "a systemic alteration" is a noun phrase used to describe a change affecting an entire system. Ludwig AI confirms its grammatical correctness and usability, especially in scientific contexts. While its frequency is rare, it effectively conveys the broad impact of a change. When writing, ensure the context clearly defines the system being altered and avoid overuse in situations where simpler language would suffice. Related phrases include "a widespread modification" and "a fundamental transformation", offering alternative ways to express similar concepts.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

a body-wide change

Replaces "systemic" with a more straightforward term emphasizing the extent of the alteration.

a widespread modification

Substitutes both "systemic" and "alteration" with synonyms that highlight the extent and nature of the change.

a global adjustment

Emphasizes the all-encompassing aspect of the alteration, using "global" to replace "systemic".

a comprehensive shift

Highlights the thoroughness of the change affecting the whole system.

a fundamental transformation

Focuses on the depth and significance of the alteration, indicating a more profound change.

a far-reaching effect

Shifts the focus from the alteration itself to its broad consequences throughout the system.

a pervasive change

Emphasizes how the alteration spreads and affects all parts of the system.

a complete overhaul

Suggests a more drastic and thorough change than a simple alteration.

an all-encompassing impact

Highlights the effect of the change, emphasizing its broad reach and influence.

a holistic modification

Uses "holistic" to stress that the alteration affects the system as a whole, considering all its aspects.

FAQs

How can "a systemic alteration" be used in a sentence?

You can use "a systemic alteration" to describe a change that affects an entire system, such as "Malnutrition is "a systemic alteration" caused by an imbalance between nutrient intake and energy requirements."

What are some alternatives to "a systemic alteration"?

Depending on the context, you can use alternatives like "a widespread modification", "a fundamental transformation", or "a comprehensive shift".

Is it more appropriate to use "systemic change" or "a systemic alteration"?

Both phrases can be correct, but "a systemic alteration" implies a specific instance of change or modification, while "systemic change" refers to the general process or state of being changed.

What is the difference between "a local alteration" and "a systemic alteration"?

A "local alteration" refers to a change that is confined to a specific area or part of a system, while "a systemic alteration" affects the entire system.