Sentence examples for a peripheral site from inspiring English sources

It was therefore hypothesized that an extra contribution in affinity may be achieved by covalently connecting a peripheral site ligand (PSL) to a non-ionic reactivator, which may result in a higher reactivation potency of the total construct.

The present case therefore differed with respect to the predictive factors for the presence of the ALK gene fusion in the cavity formation in the tumor, an initial tumor location in a peripheral site without pleural tail formation, and a patient age over 60 years old.

What happened in the wake of the assassination was that a spot on the edge of Dealey Plaza became its focal point — just as the shooting turned a peripheral site in Dallas into a place of intense scrutiny.

A peripheral site of action of endocannabinoids at the terminals of vagal afferents in the gastrointestinal tract has recently been demonstrated where endocannabinoids are involved in the complex regulation of food intake [28] as well as in a downregulation of toxin induced emesis [29].

The 10 kb pPst (pesticin) or pPCP plasmid encodes plasminogen activator (Pla), a protein that is critical to the establishment of systemic infection from a peripheral site and is also thought to have an essential role in the development of pneumonic plague [13] [17].

The two other IP6 molecules in the crystallographic asymmetric unit are bound at a peripheral site.

Using a novel combinatorial approach that is designed to target both the active site and a unique peripheral site in PTP1B, we have obtained a PTP1B inhibitor with 2.4 nM affinity and orders of magnitude selectivity against a panel of PTPs.

However, the same authors found a significantly smaller intracerebral arterial constriction compared with the constriction of extracerebral arteries – suggesting a primarily peripheral site of action for triptans.

However, a purely peripheral site of action of beta-blockers ignores their effect on attack frequency, premonitory symptoms and side effects of central nervous origin [23, 24].

They contain a deep and narrow active site groove with two separate ligand binding sites: an acylation site or A-site at the base of the groove and a peripheral anionic site or P-site at the groove mouth, with a strong electrostatic dipole aligned with the groove leading to its active site.

Worth noting here, sulfhydryl reagents, including homologs [21] of the new irreversible methanethiosulfonate-containing inhibitors disclosed in this article, reportedly form adducts with a cysteine residue at the peripheral site of a mammalian AChE engineered with a His287Cys mutation, thereby interfering with substrate binding and catalytic activity [21], [22].