a marked alteration in

USAGE SUMMARY

The phrase "a marked alteration in" is correct and usable in written English.
It can be used to describe a significant change or modification in a particular situation, condition, or context. Example: "The study revealed a marked alteration in the participants' behavior after the intervention."

✓ Grammatically correct

Science

Academia

News & Media

Human-verified examples from authoritative sources

Exact Expressions

20 human-written examples

We found that addition of 50% (v/v) spent medium from IPTG-induced E. coli DH5α cultures expressing cloned CAI-1 or AI-2 synthase genes showed a marked alteration in the phage bacterial growth kinetics in favour of the bacteria (Fig. 2; see Supplementary Fig. S1).

Nature

The preliminary results showed a marked alteration in the CD8 repertoire of the thymectomized patient but not in that of the lymphocytotic patient.

Duke University

In addition, we observed a marked alteration in meprinβ staining of proximal tubular cells despite the fact that Thy 1.1 nephritis is a glomerular disease: the immunostaining revealed a shift from a linear staining confined to the apical brush border membrane in the corticomedullary junction towards a diffuse cytoplasmatic staining involving the tubular basement membrane.

Plosone

A marked alteration in cisplatin sensitivity is observed in the conditioned cells under hypoxia, however.

British Journal of Cancer

In addition, there was a marked alteration in IL-10 expression.

BMC Pulmonary Medicine

This set of experiments also revealed a marked alteration in the levels of the Wnt pathway proteins.

Cell Death and Disease

Human-verified similar examples from authoritative sources

Similar Expressions

40 human-written examples

Such changes could occur in the absence of any marked alteration in the transcriptional landscape.

BMC Genomics

While we did not detect any marked alteration in pattern of f-actin in Vangl2 Lp/Lp ureteric bud branch tips (data not shown), it was notable that the apical f-actin pattern appeared irregular in mutant proximal-like tubules.

Human Molecular Genetics

In conclusion, in this study, we report that the gain-of-function EPOR G1251T mutation results in a marked alteration of growth and differentiation of human CD34+ and in an increase of erythroid progenitors' surface EPOR peptide.

Plosone

In addition, the treatment with PNGase F resulted in a marked alteration of electrophoretic mobility.

Plosone

In addition, a marked alteration of immune and somatic cell signaling has been implicated as an important contributor to kidney injury [ 29].

Critical Care

Expert writing Tips

Best practice

When using "a marked alteration in", ensure the context clearly defines what is being altered and the significance of the alteration.

Common error

Avoid using "a marked alteration in" without specifying the baseline state. Always provide context about what the subject was like before the alteration occurred.

Linguistic Context

The phrase "a marked alteration in" functions as a noun phrase, typically serving as the subject or object of a sentence. It describes a significant modification or change within a specified context, similar to examples from Ludwig.

Expression frequency: Common

Frequent in

Science

75%

Academia

15%

News & Media

10%

Less common in

Formal & Business

0%

Wiki

0%

Encyclopedias

0%

Ludwig's WRAP-UP

In summary, "a marked alteration in" is a phrase used to denote a significant change or modification, often found in formal and scientific writing. Ludwig's AI confirms its grammatical correctness and common usage. When employing this phrase, ensure clarity by specifying the subject and nature of the alteration. Consider alternatives such as "a significant shift in" or "a noticeable difference in" to diversify your writing. This phrase is most frequently encountered in the sciences, as demonstrated by Ludwig's examples.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

a significant shift in

Replaces "marked alteration" with "significant shift", emphasizing the direction of change.

a noticeable difference in

Substitutes "marked alteration" with "noticeable difference", focusing on the ease of observing the change.

a considerable modification in

Uses "considerable modification" instead of "marked alteration", highlighting the extent of the change.

a substantial change to

Replaces "alteration in" with "change to", offering a more direct phrasing.

a distinct transformation of

Employs "distinct transformation" to indicate a more complete or fundamental change.

a clear variation within

Substitutes "marked alteration" with "clear variation", focusing on the observable differences within something.

a dramatic modification to

Uses "dramatic modification" to emphasize the intensity and impact of the change.

a major adjustment to

Replaces "alteration in" with "adjustment to", suggesting an adaptation or correction.

a fundamental revision of

Employs "fundamental revision" to indicate a deep and impactful change.

a striking divergence in

Substitutes "marked alteration" with "striking divergence", focusing on the point where things begin to differ notably.

FAQs

What does "a marked alteration in" mean?

The phrase "a marked alteration in" signifies a noticeable or significant change or modification within a specific context or situation. It suggests that the alteration is substantial enough to be easily observed or considered important.

How can I effectively use "a marked alteration in" in a sentence?

To effectively use "a marked alteration in", clearly specify the subject that is undergoing the change and the nature or impact of the alteration. For example, "There was "a marked alteration in" the patient's condition after the new medication was administered."

What are some alternatives to "a marked alteration in"?

Alternatives to "a marked alteration in" include "a significant shift in", "a noticeable difference in", or "a considerable modification in". The best choice depends on the specific context and the nuance you want to convey.

Is it better to say "a marked alteration of" or "a marked alteration in"?

While both "a marked alteration of" and "a marked alteration in" can be grammatically correct, "a marked alteration in" is generally preferred when referring to a change within a system, context, or situation. "A marked alteration of" is typically used when referring to changing the composition or structure of something directly.