Sentence examples for Two pcg from inspiring English sources

Similarly, MEDEA and AGL19, two PcG targets [24], [25], were de-repressed in both lhp1 alleles (Fig. 7D and data not shown).

The observation that there is only a small overlap between the Su TPE s and Su var)s, combined with the observation that mutations in only two PcG loci suppress TPE, suggests that TPE represents a silencing phenomenon that is mechanistically distinct from the repression associated with either PEV or PcG silencing.

In stark contrast with this, at the moment only two PcG phosphospecific antisera exist [ 44, 52].

In addition, CBX2 and EZH2 expression was strongly correlated in a clinical SCLC cohort (R = 0.59, Figure  4C), suggesting that these two PcG proteins likely act in concert.

Since we found that CBX2 and EZH2 were consistently the most upregulated EpRs in our NEPC models, we further investigated the molecular profiles of these two PcG members.

In Drosophila, at least two PcG complexes called PRC2 and PRC1 (Polycomb Repressive Complex) and two TrxG complexes (TAC 1 and BRM) have been biochemically purified (reviewed in [ 10]).

The function of the two PcG complexes is also crucial to restrict WUS, as reducing PRC2 activity in the clf mutant leads to a substantial increase of WUS expression (Barrero et al., 2007).

Focusing on EZH2 and CBX2, we investigated whether elevated expression of these two PcG members also occurred in small cell lung cancer (SCLC), since it represents a neuroendocrine malignancy that closely resembles NEPC histologically and molecularly [ 34, 35].