According to the recommendations recently proposed by Critchley et al., in the present study we used an exclusion zone of 15%, and sufficient concordance to assume interchangeability was set to >90 to 95% [ 16].
Sufficient concordance to assume interchangeability was set to 95%, following the most conservative threshold proposed by Critchley et al. [ 19].
Concordance was calculated as the percentage of data within ± 10% 'tram line', a criterion chosen in analogy to the traditional concordance: sin θ ⋅ Δ P i C C O + Δ V o l u m e V i e w 2 < 10 % Again, sufficient concordance to assume interchangeability was set to 95%, following the most conservative threshold proposed by Critchley et al. [ 18].
These authors originally suggested that the alternative method should have an equivalent precision to the chosen reference method to postulate interchangeability of the two methods.
To allow interchangeability between our two chambers, this positioning system is fastened to a custom-machined circular plate, containing 1/4′′-20 tapped holes in a square pattern with a spacing of 3/4′′.
Bioequivalence refers to pharmacokinetics and pharmacodynamics, as well as in vitro testing, in order to ensure interchangeability of generics versus the originator or reference product.
In fact, the panicked pleading that we should vote for anyone but Corbyn speaks volumes to the interchangeability of the other candidates.
To evaluate interchangeability of a thermodilution based STAT mode continuous cardiac output (CCO) measurement method with bolus thermodilution (BTD).
The purpose of this pharmacokinetic study performed in stable renal transplant recipients was to evaluate interchangeability of Gengraf and Neoral.Using an open-label, three-period design, 50 renal transplant recipients taking stable doses of Neoral completed a multicenter study.
Nevertheless, thus far, no biosimilar maker has been able to demonstrate interchangeability.
