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Figure 1 Phylogenetic tree of GH43 enzymes annotated as characterised in the CAZy database (prepared by Dendroscope).

Animal testing as characterised in the Organization for Economic Cooperation and Development OECDD) guidelines usually just looks at apical end points and may readily detect clear-cut adverse effects.

It is important to consider how interpretation, as characterised in subsection 2.2 above, fits into the discussion of the ambit of the term legal reasoning in the opening section of this entry.

The materials chosen to simulate the head and neck parts of the phantom show an acceptable degree of similarity to normal human tissues as characterised in a number of published studies (see Table 2).

GH43 (http://www.cazy.org; Cantarel et al. 2009) includes β-d-xylosidases (E.C. 3.2.1.37) and α-l-arabinofuranosidases (E.C. 3.2.1.55) and the phylogenetic tree of 92 GH43 enzymes, which are annotated as characterised in the CAZy database (Cantarel et al. 2009; Figure 1), shows five distinct groups (I − V) representing characteristic substrate specificities.

Hence, 58 participants (28 patients with T2D and 30 persons without T2D) as characterised in table 2 were included in the analysis.

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As described above, STMN1 is studied in various numbers of cancers but is not as well characterised in bladder cancer.

The direct transcriptional regulation of VEGF by HIF, as well characterised in mammals, has been demonstrated in zebrafish (Maeda et al., 2008).

These seem likely to include regions highlighted as poorly characterised in earlier array-based maps [ 6, 7].

To date, several intermediary 'nutrient sensing' molecules, such as those characterised in Saccharomyces cerevisiae and bacteria, have been implicated in directing amino acid signalling to mTOR [ 23, 24].

The results shown in Table  1 support the observation that although a phenotypically-similar EMT is induced, as extensively characterised in previous reports by us and others [ 3, 41- 43, 46- 48], there are differences in the molecular mechanisms that drive these phenotypic changes.

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