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The brains of older people are sometimes peppered with dark splotches where blood vessels have burst and created tiny dead zones of tissue.
Insets: High power views of tissue outlined in black showing four zones of tissue: ligamentous tissue (L), uncalcified fibrocartilage (UF), calcified fibrocartilage (CF), and bone (B).
Thus heterogeneous zones of tissue pO2 may reflect some degree of cell-state specificity as well as local metabolic demand that changes constantly even within a small specific area/volume of the brain.
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The major basement membrane heparan sulfate proteoglycans include collagen XVIII (Col18) and perlecan found ubiquitously in the vascular basement membrane zones of tissues, and agrin, a critical component of the neuromuscular junction basement membrane [2], [3], [4].
The beta-expansin proteins were originally viewed exclusively as group 1 pollen allergens but are now considered to be important in cell wall changes during growth in vegetative tissues of grasses and dicotyledon plants [ 18], most notably in development and growth zones of tissues such as roots [ 20, 21].
The generative role is discharged by an ill-defined zone of tissue called the promeristem.
Dr. Anversa's team focused on two areas -- the zone of tissue bordering the site of a heart attack and a more distant area of the heart.
The first signs of the differentiation of the vascular system appear some distance below the apex, in a zone of tissue distinguishable by the smaller cross-sectional area of individual cells.
There is no distinct stalk, although it is evident as a short, semitransparent zone of tissue at the base of the club.
By our main hypothesis, limb skeletal patterning is established by a LALI process within a reshaping zone of tissue in the presence of a distal suppressive gradient.
It seems reasonable to conclude that negative pressure between -50 mmHg to -150 mmHg applied to the zone of tissue surrounding the incision is the principle component of the effect, although much scope remains for investigation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com