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This does not agree with our results since miR-520c is upregulated in malignant tissues compared to normal tissues, regardless of zonal origin.
Evidence from a study on radical prostatectomy patients also indicates that time to biochemical failure is independent of zonal origin of the tumour (Chun et al, 2007).
The array was constructed to address the speculation that variation in biomarker expression could define signatures associated with the zonal origin of tumors.
At the same time, the clustering and principal component analysis indicate that also the non-significant changes in miRNA expression between tissues from the two zones are large enough for detection of zonal origin (TZ or PZ).
As phenobarbital-induced expression of both CYP2B1/2 and 3A1 in normal liver is heavily localized to the centrilobular zone, these observations suggest that the ability of preneoplastic nodules to respond to induction of these P450 proteins is determined primarily from the zonal origin of the precursor hepatocytes.
Represented in the TMA were 15 cases of Gleason score 6 (3 + 3) carcinoma consisting of tumors of transition zone (5 cases) or peripheral zone (10 cases) origin defined by established histopathological criteria, that enabled an assessment of the potential variability of individual biomarker expression as a function of zonal origin of the tumor.
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The origin of the zonal horizontal axis represents the location of maximum precipitation.
In the present paper we consider the small-scale IGWs with small amplitude as the formation mechanism of zonal electric fields of seismogenic origin in the Earth's ionosphere.
Lemma 3.4 If Φ p is an L p Blaschke-Minkowski homomorphism, which is generated by the zonal function g, then for every origin symmetric convex body K ∈ K e n, π k h ( Φ p K, ⋅ ) p = g k π k S p ( K, ⋅ ), k ∈ N, (3.10).
From their origin (probably in the Emsian Age) the evolution of goniatite ammonites, as well as other ammonites, allows detailed zonal subdivisions to be established until the end of the Cretaceous Period.
The zonal structure is remarkably conserved between the modern hydrothermal vent systems and the ancient volcanogenic massive sulfide (VMS) deposits of hydrothermal origin.
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