Exact(3)
The collapse of institutions meant to serve and protect citizens – from the criminal-justice system (which is so dysfunctional that in 2008 there were zero trials and zero convictions in the 179 murders committed that year) to our hospitals (many of which are still not open after Katrina) – is making death all too familiar and comfortable.
In this scenario, Phase 0 (zero) trials should allow an early evaluation in humans of pharmacokinetic and pharmacodynamic profiles of test compounds through administration of sub-pharmacological doses and for a short time period to a low number of humans.
Efficacy testing of these drugs in xenograft models, however, does not always reflect the heterogeneity of human breast cancer - and the concept of early phase zero trials as proof of concept may be an effective way to anticipate failure and to reject ineffective drugs before larger scale clinical development is triggered.
Similar(57)
And three trials?
Three trials have been held.
There were two trials, Fatma explained.
He said ESPN planned four trials annually.
The first of two trials is underway.
Four trials resulted in three acquittals and one mistrial.
Three trials superimposed.
There were four trials.
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