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We found that the subjects with one DPB1*05:01 allele (OR = 2.37, 95% confidence interval [CI] = 1.72 3.62) and those with two alleles (OR = 2.25, CI = 1.51 3.34) had similar OR compared to the individuals with zero allele, suggesting that HLA-DPB1*05:01 confers susceptibility through a dominant mode of inheritance (Table 3).
We provide such a link by distinguishing between positive, negative and zero allele interaction at the genotype level.
First four loci represented the 5′-modules, and zero allele indicated the lack of the particular 5′-module(s) in bimodular and monomodular RCCX structures.
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MST12 (ETR-D) exhibited four alleles including one allele derived from M. tuberculosis H37Rv reference strain sequencing.
The RVA result revealed that i and j alleles from each of six allele groups contributed to parameters of starch paste viscosity properties differentially.
In the alignment (Additional files 7, 8), two heterozygous alleles were tentatively sorted into two allele sequences.
Thus, in subsequent analyses, we considered only three allele groups (S2, S3P, and L alleles), with six corresponding genotypes [ 12].
In this study, we establish the paramount role of one allele (HLA-DPB1*05:01), discover two novel associated alleles (DQB1*03 02 and DRB1*15:01), provide convincing replications of other three alleles (B*46 01, DRB1*12 02 and DRB1*16:02), and exclude independent effect of one allele (DQB1*05:02).
Three individuals showed ambiguous allele classifications for HLA-B, such that one of the HLA-B alleles could belong to one of two allele groups.
Germline heterozygous alleles were generated by crossing founder mice carrying the R120G mutation on one allele with C57BL6 mice.
Six allele groups can be classified into two AC groups depending on the Wx allele.
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