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The increase in coverage is more pronounced in African HapMap samples, reflecting the dense marker tagging for YRI in the IBC array.
Because there is no Costa Rican population in the HapMap Project for which we could select SNPs, we included tagging for the YRI in addition to the CEU population to improve our probability of achieving gene coverage in our population.
Map and pedigree files were not available for chromosome X in the 1000 Genome YRI in the LocusZoom package.
The eQTL identified in YRI in the conventional pipeline vs the RNA-seq pipeline offer a further source of comparison.
Because we used unphased CEU and YRI in HapMap3 as source populations (SP1) for HapMap3 Mexican samples and used phased CEU and YRI in 1000G as source populations (SP2) for 1000G Mexican samples, this high concordance suggests, indirectly, that the phasing of CEU and YRI in 1000G is reliable.
This left 14 probe sets (including WRN) that were differentially expressed across the CEU and YRI in the immortalized cell experiments.
Similar(48)
However, a number of cis-regulators can be identified only by using the gene-based PLS; 136 cis-acting genes (75 in YRI, 56 in CEU, 55 in CHB, and 46 in JPT) could not be identified by using only SNP-based PLS.
Frequencies of SNPs in the HapMap populations: Yoruba in Ibadan, Nigeria (YRI), Japanese in Tokyo, Japan (JPT), Han Chinese in Beijing, China (CHB), and Utah Residents with Northern and Western European Ancestry (CEU), and the recombination rates between SNPs were derived from the HapMap project (Release #22) [ 35].
The LD values were lower in YRI than in CEU.
The LD related to the larger deletion frequency was lower in YRI than in CEU.
We obtained a maximum DAF score for all three site classes for only two and six polyPSGs when using eQTLs detected in YRI samples in the studies performed by Lappalainen et al. (2013) and Pickrell et al. (2010), respectively, limiting the power of this analysis in the YRI population.
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