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In the families analysed in our study MSI analysis is performed in the tumour of the youngest relative available.
If two or more first-degree relatives were eligible for the analysis, then only the youngest relative was included (Nexcluded=12 561).
This selection is not expected to have a large influence, because MSI analysis in the families in our study is performed in the tumour of the youngest relative available.
Recommended surveillance should be performed with pelvic examination, transvaginal ultrasound, and CA-125 levels every 6 months beginning at age 30 or 5 10 years earlier than the youngest relative diagnosed with OC [ 100, 102].
It seems advisable to follow the guidelines for mammography in this aspect and start screening at an age 5 years younger than the youngest relative that presented with cancer.
The risk of developing breast cancer in a gene carrier depends on a large number of factors including the penetrance of the mutation, environmental influences, the age of the individual and the age of the youngest relative when they developed breast cancer.
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I first came at the story through a younger relative of Iris.
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