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In some families, such as those of proband 0017 and 1018, there was no younger case with breast, colorectal, gastric or pancreatic cancer available for testing.
However, the intervention team agreed that this younger case (age of this participant was 69 years) fitted well into the model.
We oversampled younger case patients and African-American case patients to maximise their numbers in the study, and we randomly sampled older White case patients to achieve approximately equal numbers of case patients in each 5-year age group.
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The frequency of short rare alleles was higher in younger cases (<50 years) than in older cases (≥50 years).
Interestingly, our tailored analyses suggest (non-significantly) that older cases may be more infectious than younger cases, which had not been observed before.
Results from linear regression showed that age had a significant effect on hospitalization where younger cases tended to be hospitalized more rapidly independent of sex (p = 0.010).
Among cases in the most commonly reported clonal complex, ST-21, incidence among younger case-patients (0- to 14-year-olds) was higher in the suburban area, but for all other age groups, the incidence was higher in the rural area.
The frequency of rare alleles was higher in younger cases (4.9%) than in older cases (1.3%).
Interestingly, the majority of errors were misclassifications of cases from the older cohorts as younger cases.
This resulted in a higher proportion of younger cases than seen nationally (Table 1).
Samples with higher expression of a poor outcome-associated proliferation signature were predominantly (65%) younger cases.
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CEO of Professional Science Editing for Scientists @ prosciediting.com