His postdoc Martin Schwarzer showed that young, germ-free mice don't put on as much muscle or grow bones as big as mice that have the normal complement of bacteria, even when they eat the same amount of food.
Following up on this observation, the authors demonstrated that colonisation of young germ-free mice with microbiota from conventionally reared mice produces a 60% increase in body fat mass that is associated with increased insulin resistance, despite lower energy intake.
Colonization within two weeks of young germ-free mice with microbiota from conventionally reared mice is associated with increased insulin resistance and provokes a 60% increase in total body fat mass despite lower energy intake [ 13].
The youngest male germ cells, including primordial germ cells and gonocytes, can be used in the construction of diploid embryos by nuclear‐transfer cloning.
Association between HuR and MVH was confirmed by reciprocal co-immunoprecipitation experiments (coIP) using anti-MVH (Figure 3B) or anti-HuR (Figure 3C) antibodies on cytoplasmic extracts of young adult male germ cells.
Mouse round spermatids the youngest haploid male germ cells appear first at 17 days after birth and can be used for the production of offspring by round spermatid injection (ROSI) into oocytes [9].
My mum was involved in a traffic accident; my dad, I was told from a very young age, "got a germ in his eye".
In mice embryos, Sp7/osterix is expressed in young differentiating chondrocytes and germ tooth mesenchymal cells, but not in condensed chondrogenic mesenchyme nor in later chondrocytic cells [ 5].
Commonly, fertility-sparing surgery (FSS) has been selected in young patients with borderline, germ cell, and stromal tumour, and several investigators have proposed the use of this surgical procedure for stage I/grade 1 invasive EOC.
Since anaemia is a major problem in dose intensive therapy in the young patient population with germ cell cancer the effects of erythropoietic growth factors on the frequency of transfusions, quality of life and potentially also on overall response to chemotherapy should be further studied.
