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Young cells did respond to the proteasome inhibitor lactacystin, but not to lysosomal inhibition by NH4Cl/Leu, suggesting that young cells used preferentially or exclusively the UPS for polyUb-protein degradation.
This indicates that in young cells gravitaxis can be explained by a physical mechanism only to a small extend.
Notably, the output of A-beta-chewing enzymes in these young cells was robust.
They look like young cells," said Dr. Cristofalo, who is on Geron's board of scientific advisers.
Moreover, it appeared to reduce the rate of aging in young cells.
Inoculating with young cells significantly shortened the initial lag-phase and using the same inoculum improved the reproducibility of the current time curves.
If the young cells are present in sufficient number, the anemia temporarily becomes macrocytic (but not megaloblastic).
It is not just that they undergo more divisions; they also divide at a speed typical of young cells.
EPM of old cells was identical to young cells in polymer-free media yet was 4% greater in dextran.
Young cells are uninucleate, whereas mature cells may have up to eight nuclei.
During this stage fruits consist of small, young cells filled with protoplasm.
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