FBA further imposes an objective that the model should optimise (e.g. minimal effort to produce a compound or maximisation of biomass34), which yields a unique optimal value.
Paul Sennett from SPX looks at how engineers should optimise the filtering of air for their gas turbines – through improved pressure drop, regular cleaning and maintenance, and by taking a consultative approach – ensuring that all environmental factors are taken into account before a filter is specified.
"It led me to Lotka's maximum power principle [PDF], according to which bird species' distributions should optimise a yearly energetic balance given the environment and competition with other species.
Protocols should minimise the use of multi-phase studies and should optimise settings to reduce the dose as much as possible without losing image quality.
The adoption of LW can be important for dispersal, when juveniles should optimise displacements through hostile habitats, without a-priori knowledge of resource distribution.
In such cases, users should optimise their stainings first to obtain image qualities of the defined specifications and show go through rounds of improvement (changing the parameters as shown in Table 3) and validation against their own data to achieve the desired accuracy.
Such a strategy should optimise the trade-off between detection rate and cost.
This is encouraging for potential future intervention, as admission to a hospital capable of providing definitive care should optimise outcomes.
Based on the results, algorithms were written that should optimise identification of nursing-sensitive outcomes in paediatric populations (Table 1).
A combination of these two guidelines should optimise the dosing of warfarin in cardiothoracic patients and contribute to an overall improvement in their care.
