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The phrase "you are up" is grammatically correct and can be used in written English.
It is a common phrase used to indicate that someone's turn has come or that they are in a position to act or participate. Here are a few examples of how it could be used in a sentence: 1. "It's your turn to bat, you are up next." (in a game of baseball) 2. "The meeting will start in 5 minutes, so please make sure you are up and ready to go." (in a business setting) 3. "Congratulations, you are up for a promotion!" (in a job or career context) 4. "I know it's early, but you are up for a sunrise hike tomorrow, right?" (in a casual conversation) 5. "After weeks of procrastination, you are finally up to finish that project." (in a personal or academic setting).
Exact(60)
Tell us what you are up to!
"I know you are up there".
Assess what you are up against.
When you are up then you must know that you are up!
Video cameras record what you are up to.
If you don't love them, you are up a tree".
You never know what you are up against.
Imagine that you are up late writing a report.
"You are up for reëlection right now," she said.
"When you are up on yourself, you interview better".
You're "high-level" because you are up in the sky.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com