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While down-regulated genes were less consistent across models with only two genes (Abcg2 and Egr1, shown in Fig. S2) downregulated in 4 or more conditions, upregulated genes were more consistent yielding a list of 94 dysregulated in 4 or more conditions (Fig. S2).
We next identified all diseases defined by MeSH that have at least 20 associated genes in the current OMIM and GWAS database17,18, and then filtered out overly-inclusive diseases, yielding a list of 70 diseases (see Supplementary Section II). Figure 2: Localization statistics for 41 tissues where a significant fraction of expressed genes forms a connected subgraph.
SimilarWeb essentially provides a user-driven site suggestion and rating service, by accepting any website name a user enters, and yielding a list of related sites and data.
Once a query is submitted, both the natural and artificial/empirical linkers in SynLinker are searched simultaneously, yielding a list of potential linker candidates satisfying the desired selection criteria together with information about the AA composition radar chart and the conformation of the selected linker, as well as the fusion protein structure and hydropathicity plot [350].
Using laser capture microscopy, we developed an analytical approach for the identification of novel epicardial genes, yielding a list of potentially interesting genes for epicardial function that has not been possible with more traditional, less high-throughput approaches.
Scored lists were filtered again by adjusted p-value (<0.05) and fold change (1.5) and probe sets not meeting these criteria for both strains were excluded yielding a list of 910 probe sets.
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This list was further supplemented with genes for vacuolar proteins, yielding a final list of 542 P. pastoris genes, about 10% of the genome.
This approach balanced the explanatory power of the model against model complexity, yielding a parsimonious list of factors that influenced the trait of interest.
All genes showing an at least 2 fold higher expression in the trachea compared with the remainder of the larvae were chosen, yielding a total list of 413 genes [see Additional file 2].
For this analysis, the 300 most abundant tags were retained from each library, yielding a merged list of 1128 unique tags.
To avoid repetition, we removed overlapping items from the HTQ, yielding a final list of 23 items.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com