In your talk today you said that your postdoctoral project did not yield any major results.
The major result yielded by phylogeographic inferences is a split of Pandion in four clades that appear to have diverged from each other within relatively short time.
This approach has yielded two major tangible results: (a) in our main study cell lines, MCF10AT1 (i.e. P20E) as well as in MCF-7(P35E) cells, E2 was the most effective agent, among tested in terms of eliciting AhR overexpression, and (b) E2 selection resulted in transformed cells with a phenotypic expression of the increased cell proliferation in both cell lines.
Search against predicted L. major proteins yielded no results.
Most systemic approaches have yielded disappointing results despite major side-effects.
Recently, numerous trials targeting miRNA have been conducted by researchers and biopharmaceutical companies using cationic lipids, polymers, nanoparticles and so on as delivery reagents for more stable, safer and more effective drug delivery systems (Uchino et al, 2013), and some have yielded good results without major adverse effects.
However, a separate analysis of patients with response assessed at 6 months (n=108) yielded similar results, making a major impact of follow-up time-point unlikely.
In women with moderate to severe depression or anxiety, antidepressant medication is the treatment of choice and the use of estrogen in such cases remains controversial.[ 27, 28] Studies using estrogen to treat major depression have yielded mixed results.[ 29, 30] The use of unopposed estrogen is contraindicated in women with intact uteruses.
To our knowledge, few studies have examined the benefit of whole-body CT on mortality in patients with major trauma and these yielded conflicting results [ 4- 6].
