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Presented Vietnamese style — with lettuce, chiles and mint for bundling, and nuoc cham, tempered with Meyer lemon, for dunking — they yield potent, gratifying handfuls.
To yield potent inhibitors of beta-amyloid (Abeta) aggregation, we synthesized small molecules that increase their steric bulk by binding to chaperones but also have a moiety available for interaction with Abeta.
We describe an optimized series of acyclic hydroxyethylamine transition state isosteres of β-secretase that incorporates a variety of P2 side chains that yield potent inhibitors with excellent cellular activity.
Australian sponges yield potent chemicals for treatment of falciparum malaria - one of the most lethal and drug-resistant forms.
The 2-thio-3-SO3Na and glutamic surface groups did not yield potent dendrimers.
Thus, our data demonstrate for the first time that a straightforward shRNA-library construction protocol in line with a stringent cellular selection procedure yield potent and readily convertible shRNAs against a viral genome.
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Small-molecule screening and subsequent optimization have yielded potent and specific activators and inhibitors of this process.
However, when crushed, the tablets yielded potent quantities of drug that could be snorted, injected, or swallowed to produce a powerful high.
This strategy yields potent inhibitors of Abeta aggregation and could lead to therapeutics for Alzheimer's disease and other forms of neurodegeneration.
Structure guided optimization effort yielded potent and stable 11β-HSD1 selectinhibitoritor 42.
On the other hand, the modification within a multi-Leu core in combination with the incorporation of a C-terminal 4-amidinobenzylamide (Amba) residue yielded potent cyclic analogues.
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