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However, even the most optimistic clinical trials yield efficacy rates of 70% and 40% for antidepressant and placebo, respectively [ 11].
In the case of SQ109 and BTZ043, the dose reported earlier to yield efficacy in the chronic mouse model was chosen for the combination study.
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A recent phase III study showed that pemetrexed plus cisplatin yielded efficacy results in advanced NSCLC comparable to those for gemcitabine plus cisplatin (Scagliotti et al, 2008).
Similarly, Hale et al. [ 65] found that an MPA AUC of 15, 25 and 40 μg × h/mL yielded efficacy rates of 50%, 75%and90%0% following kidney transplantation.
The TIP regimen as applied in this study yielded efficacy and survival figures comparable with those obtained in three other published studies (Zanetta et al, 1999; Dimopoulos et al, 2002; Choi et al, 2006).
The TICb regimen, as applied in this study, yielded efficacy and survival figures that compare favourably with those obtained in other GOG studies with ifosfamide+cisplatin (Sutton et al, 2000), paclitaxel+ifosfamide (Homesley et al, 2007) and a recently completed phase II study with paclitaxel+carboplatin (Powell et al, 2010).
A randomized controlled selective cross-over trial was performed to compare the diagnostic yield and efficacy of ExEm foam (HyFoSy) with saline medium (HyCoSy) as a contrast agent for hysterosalping-contrast sonography in subfertile patients.
Generally, combination therapies yield better efficacy with fewer side effects, hence combination therapies are widely used in cancer treatment.
Wild type virus could not be used because it did not yield any efficacy in the model (Fig. 3).
A completed Phase III randomised clinical trial can yield unequivocal efficacy data.
These novel anti-inflammatory agents appear to be better tolerated and they can yield similar efficacy as anti-TNF biologics.
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