Exact(25)
GrB is naturally expressed as a pre-pro-enzyme, that requires stepwise removal of the signal peptide and an N-terminal activation dipeptide to yield active protein [31].
A detailed view of the reaction scheme is presented in Figure 2. Notable features of our model include activation of immediate early TFs by signaling kinases, combinatorial interactions among the TFs to yield active dimer forms, and a subset of these TFs influencing their own dynamic activity via regulation of corresponding genes.
Arg156 > His, the product of which had detectable activity, was found in three patients whose second alleles were unlikely to yield active ADA.
The model includes the binding of free receptors R to ligand L with forward rate k on and reverse-rate k off to yield inactive receptor-ligand complexes, C. Receptor-ligand complexes are reversibly activated with forward rate k fr and reverse-rate k rr to yield active complexes C a. Activated complexes are irreversibly desensitized at rate k ds.
delta 9 -Tetrahydrocannabinol (Δ9-THC), the primary psychoactive constituent of marijuana, is subject to first pass hepatic metabolism primarily by hydelta 9 -Tetrahydrocannabinolnd inactive oxygenated products.
CoTiOx and NiOx water oxidation cocatalysts were deposited onto the Si-Ta3N5 to yield active photoanodes that with NiOx retained 50-60% of their maximum photocurrent after 24 h chronoamperometry experiments and are thus among the most stable Ta3N5 photoanodes reported to date.
Similar(35)
Further, only 2 out of the 4 possible VH/VL orientations/arrangements in bDAb construction yielded active products that retain binding activity to both EGFR and IGFR.
With co-substrate 6 e′, the substrate yielded active product mixtures with all four catalysts, with the highest activity for [Rh2 OAc 4].
Inducible expression of the rhdA gene under the control of the hybrid T7-lacO promoter yielded active r-RhdA over a 4-h period, though r-RhdA-expressing E. coli showed decreased viability starting from 1 h post-induction.
The control reporter is a yeast expression vector containing Renilla and firefly luciferase genes, which yields active Renilla and firefly luciferase proteins.
It has been shown previously that overexpression of IKK2 absent NEMO in Sf9 and yeast cell cultures yields active IKK2.
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