We previously found the Krause rating scale to have a problem with a narrow range of scores [ 22], and our enhanced training did seem to yield a broader range of scores.
Their hypothesis-testing approach identifies two new targets but raises the question 'How many targets are there?' Given that ErbB-3 and -4 were upregulated at the protein level and not the mRNA level, a more global set of approaches to kinase and kinase substrate identification [ 13] in endocrine-resistant disease may yield a broader range of targets.
Assaying the prioritized hits against the high- and low-iron conditions (25 and 2.5 µM, respectively) yielded a broad range of IC50 shifts, including instances of a decrease in IC50 at the higher Fe(II) concentration tested, as well as several increases in IC50 of greater than 10-fold at the high Fe(II) concentration.
The nature of the disease yields a broad range of patients - from the young and healthy to the elderly with multiple comorbidities.
These yielded a broad range of transcript levels, and it was necessary to place some boundaries on what transcript levels can be confidently ascribed to be above background levels.
The two key points to note are that the 180 condition Screen 2 Box-Behnken analysis yielded a broad range of different growth rates and final biomass densities (light to dark green) and that some of the conditions tested yielded culture densities much closer to those obtained with the TAP control than was achieved in Screen 1.1.
Our regional PET measurements confirmed that the model also yields a broad range of regional lung expansion with minimal hyperinflation (no regional fgas value above 0.9) and appropriately reflects the lung recruitment and reduction in shunting in dependent lung regions produced by protective ventilation.
By contrast, MO inhibition of cathepsin K expression yielded a broader range of corrected phenotypes.
The PAML mcmctree program [ 52] yielded a broader range of somewhat older dates (935 - 1,197 Mya), with the 95% confidence interval from 702 Mya to 1,808 Mya (Additional file 1).
For such samples, the same dCt values were yielded for a broad range of template input, from 150 ng/reaction down to 1.5 ng/reaction (Figure 3A).
