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YFJ performed the computational experiments.
Analyzed or reviewed the data: NTN, MLL, and YFJ.
Wrote or edited the paper: NTN, MLL, and YFJ.
Conceived and designed the experiments: NTN, MLL, and YFJ.
YFJ, HCH, and MLL designed the research; JB, and QD performed animal experiments.
YFJ, HCH, and MLL analyzed the results and wrote the manuscript.
YFJ, and YH designed the research; OG, TY and NN performed computational simulation.
YFJ, YFO and CJM treated the patient, CSC and YTK collected data and drafted the manuscript together with CJM.
Contributed reagents/materials/analysis tools: NTN and YFJ.
JMY and YFJ designed the small RNA sequence analysis.
YFJ and YZZ conceived, and carried out the design and draft of the manuscript.
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