YFJ performed the computational experiments.
Wrote or edited the paper: NTN, MLL, and YFJ.
Conceived and designed the experiments: NTN, MLL, and YFJ.
YFJ, HCH, and MLL designed the research; JB, and QD performed animal experiments.
YFJ, HCH, and MLL analyzed the results and wrote the manuscript.
YFJ, and YH designed the research; OG, TY and NN performed computational simulation.
YFJ, YFO and CJM treated the patient, CSC and YTK collected data and drafted the manuscript together with CJM.
Contributed reagents/materials/analysis tools: NTN and YFJ.
JMY and YFJ designed the small RNA sequence analysis.
OG, TY, MLL, YH., and YFJ analyzed the results and wrote the manuscript.
The authors acknowledge grant and contract support from NSF CAREER award #0644646 (to HCH), NHLBI HHSN268201000036C (N01-HV-00244), NIH R01 HL75360, Veteran's Administration Merit Award, and the Max and Minnie Tomerlin Voelcker Fund (to MLL), and NIH 1R03EB009496, and NIH SC2HL101430 (to YFJ).
