So when the magnetic doctor, Astrov, played to beguiling, vodka-soaked perfection by Hugo Weaving, talks of a brighter future for generations yet unborn, we intuit even more profoundly than usual that it's a future he doesn't believe in.
But he was wrong about Iraq, acted wrongly in Iraq and should publicly apologise far more profoundly than he has yet had the humility to do.
Into that landscape come three exciting newcomers that are changing the market much more profoundly than the slow-moving incumbents yet realise.
In yet another portrayal, the cultural origins of "nuclear fear" may be rooted more profoundly in our shared myths if not even human consciousness.
During the course of my life almost nothing has changed more profoundly than our society's story of time and yet we do not seem to notice it.
"We don't know yet whether this treatment will be as safe and effective in patients with more profoundly impaired liver function," said Dr. Louis M. Weiner, a specialist in gastrointestinal tumors at the Fox Chase Cancer Center in Philadelphia.
Yet more than ever in my lifetime, we collectively face a number very real and profoundly serious issues.
Yet "The View From My Pew" implies a hope for change and a longing to connect more profoundly with the Holy Father and the church.
Yet, there is another world in which the distinction between a real market and an expectations market is much more profoundly understood -- the National Football League NFLL).
They're more profoundly about identity.
