Yet, early discontinuation of cinacalcet was frequent and resulted in the loss of control of PTH, calcium, and phosphorus.
In fact, 20 participants had only had one follow-up visit by the time of discontinuation, yet 12 of these completed their remaining eleven months of follow-up.
While this series was too small to find a statistically significant effect of topical corticosteroid on biopsy result, it may be prudent to discontinue topical corticosteroid prior to conjunctival biopsy to optimize biopsy yield, although the ideal length of time of discontinuation is yet to be determined.
Interestingly, 12 patients had radiographic evidence for intracranial hemorrhage prior to receiving bevacizumab, yet only 1 patient required discontinuation of bevacizumab due to progression of hemorrhage.
One patient received 12 cycles, discontinued the study for an unrelated medical condition and, at the time of discontinuation, had an increase in tumour size not yet reaching disease progression.
In the ATTRACT study, the combination of infliximab and methotrexate over 30, 54, and 102 weeks provided significant, clinically relevant improvement in a majority of patients with RA who had an incomplete response to methotrexate alone; however, discontinuation rate data at 102 weeks have yet to be made available [ 11- 13].
Preliminary, yet unpublished, data from our department support the possibility of gradual drug discontinuation in responders.
Yet, a distinct signal towards a possible increase of ischaemic events after discontinuation of clopidogrel at six months has been specifically observed after sirolimus or paclitaxel eluting stents but not after cobalt-chromium everolimus eluting stents.
Most antidepressants are inactivated and eliminated within days to a week after use, 26 yet the potential carry over effect on the risk of postpartum hemorrhage after discontinuation of is unknown.
Not quite yet, but a statement made yesterday by a high-ranking Food and Drug Administration official supporting the discontinuation of antibiotics to promote livestock growth offers a glimmer of hope that the days of heavy antibiotic use in livestock may be coming to an end.
