There is a possibility that one or more of the other six vertebrate Src family kinases might compensate for lack of these three, particularly Fyn, Yes, and c-Src, which are expressed in myeloid cells.
The importance of c-Src in PyV mT-mediated tumour progression has been demonstrated by crossing the MMTV/PyV mT strains to c- src-and c- yes-deficient mice [ 28**].
To further link Src kinase activity to phosphorylation of Y1173 of VEGFR-2, we tested the phosphorylation of Y1173 of VEGFR-2 in the triple knockout SYF (c-Src, c-Yes and c-Fyn) cells [24].
Meanwhile multiple Ser/Thr-kinases including specific PKC isoforms, ERK1/ERK2, CK1 and CK2 (former casein kinase 1 and 2) and Tyr-kinases such as c-Yes and c-Src have been reported to interact with and phosphorylate occludin [ 16].
There were three response options: (a) yes, (b) no and (c) uncertain.
Mouse knockout cells deficient in focal adhesion kinase (FAK-/ cells) or fibroblasts derived from c-src-/-, c-yes-/-, and c-fyn-/ triple knockout mouse embryos (SYF cells) as well as stable expression of wt FAK in FAK-/ cells or wt c-Src in SYF cells have been already described [ 41, 42].
"And C, yes I am too old, so D, what does that mean?" Mr. Irwin is not all that old for an actor, but the shelf life of a clown known for his physical prowess is shorter.
The campaign has made lots of people angry though, including me, because every time I shave my legs I am reminded of what a huge waste of time and energy I have to put up with purely to a) not repulse men, b) not be stared at and humiliated when in public in summer, and c) yes, to feel "womanly".
To our surprise, we found all cell types examined strongly expressed c- ets, c- src, and c- yes.
Superset The input is a concept D and the output is yes if (C sqsubseteq D) and no otherwise.
