Blue: negative interactions, yellow: positive interactions.
The red boxes denote the residues of Fz4 that contact with Norrin, whereas residues of Fz8 are boxed in blue to indicate binding to Wnt8 index finger (site 2) and in yellow for interaction with Wnt8 PAM (site 1).
Moments later, gambling on a yellow-colored interaction, Plucky saw his first major victory.
Green line: HBA, Blue Line: HBD, Rose Line: hydrophobic interactions and Yellow line: π-cation interaction.
Blue colour indicates negative genetic interactions and yellow are positive genetic interactions.
A) The ATP binding site with specificity-conferring interactions: the position of an atom accepting a hydrogen bond from Lys 89 (red-dotted sphere) and a hydrophobic interaction (yellow sphere).
Compounds are showed in sticks; hydrogen bonds are shown as dashed yellow line; pi pi interaction is shown in orange line; shades of brown indicate regions of high hydrophobicity; shades of white indicate regions of neutral, shades of blue indicate regions of low hydrophobicity.
Figure 8a shows the ligand, Soraphen A, in yellow and the interaction path in green.
Black, zinc cation; green, zinc-coordinating residue, red, zinc-coordinating Cys targeted for mutagenesis; yellow, zinc-chelating interaction.
Black edges represent physical interactions, light yellow edges represent positive genetic interactions, and light blue edges represent negative genetic interactions.
