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Preliminary studies suggest that humans follow the yeast paradigm, with the early appearance of recombination and cohesion proteins during prophase [ 13, 14].
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The yeast paradigms long stood alone, but we now know that DNA sequence elements also help to position meiotic recombination at hotspots in mammals (Myers et al. 2008; Baudat et al. 2010).
The stress-induced, uORF-mediated regulation of GCN4 translation in yeast established the paradigm for this mode of regulation (Dever et al., 1995; Grant et al., 1995).
Budding yeast provides important paradigms for nucleation, propagation and questions of dosage dependence for heterochromatin, whereas S. pombe has contributed many of the models currently explored on how RNA contributes to transcriptional repression in the nucleus.
Under this ageing paradigm, haploid yeast are grown in synthetic complete medium (SDC) until nutrients are depleted.
Here, we investigate the requirements for establishment, spreading and maintenance of heterochromatin using fission yeast centromeres as a paradigm.
A relatively simple genome and the availability of powerful methods for their genetic manipulation make yeast models the central paradigm in systems biology.
In some cases the structure of yeast flavoproteins served as paradigms for a family of enzymes, for example yeast OYEs [6,29] and more recently kynurenine monooxygenase [30].
Deregulated growth signaling and inappropriate entry into, or exit from, the cell cycle in nutrient-starved budding yeast cells provide a new paradigm for investigating how oncogenic activation of growth-regulatory pathways and the induction of replication stress in mammalian cells contribute to cancer and other age-related diseases.
Our detection of two H4 molecules per nucleosome in the fission yeast central domain fits this paradigm.
Hence, the yeast enzyme also became the paradigm for the class of "ene-reductases" now widely used for the synthesis of a variety of useful chemicals.
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