Sentence examples for yeast model from inspiring English sources

We report a yeast model to define mechanisms governing TDP-43 subcellular localization and aggregation.

Here, we exploit a yeast model and purified FUS to elucidate mechanisms of FUS aggregation and toxicity.

For this we screened an established yeast model to identify genes that when overexpressed alter alpha-synuclein toxicity.

Recently, a yeast model carrying human disease-linked α-synuclein transgenes was engineered.

This suggests that the yeast model reveals specific aspects of the underlying biology of the disease protein rather than general cellular stresses associated with accumulating misfolded proteins.

We recently developed a yeast model to study the ALS disease protein TDP-43 (Johnson et al., Proc Natl Acad Sci USA 2008).

Because of its short generation time and well-characterized genome, a major experimental advantage of the yeast model system is the ability to perform genetic screens to identify genes and pathways that are involved in a given process.

Drug-based studies have yielded significant insight into UPR function, but meiotic UPR induction provides the first physiological yeast model of timed induction akin to that seen in differentiating mammalian cells.

We have used the yeast model system to identify the mechanisms by which TDP-43 aggregation contributes to ALS and to identify approaches to protect cells from the toxic effects of TDP-43 aggregation.

In prior work, we established a yeast model to study the action of artemisinin.

In this report, we utilized a yeast model to decipher the cytotoxic action of binaphthoquinones.