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Revenue sharing pools in future years will be calculated proportionately.
For each patient, quality-adjusted life years will be calculated as the area under the EQ-5D utility curve.
Quality-adjusted survival times per life years will be calculated for all randomised patients using the HRQoL measures.
Estimated risk at 10 years will be calculated according to the Framingham risk scales for stroke and global cardiovascular morbidity-mortality [ 22].
Clinical endpoints will not be assessed, but the absolute risk of cardiovascular events in 10 years will be calculated using the risk table from the Dutch guideline for CVRM [ 6].
For adverse event (AE) and serious adverse event (SAE) incidence, rates based on the number of included patients and incidence density based on the number of events/ patient years will be calculated.
Similar(54)
The number of pack years (1 pack year = smoking 20 cigarettes per day for one year) will be calculated.
With this sample a rate of weighted global incidence of between 1 and 4 exacerbations/person-year will be calculated with a precision of at least ± 0.4.
Long-term cost-effectiveness over 5-year and 10-year periods will be calculated using a Markov model.
Quality-adjusted life years (QALYs) will be calculated using linear interpolation between time points.
In a secondary cost-utility analysis, quality adjusted life years (QUALYs) will be calculated based on EQ-5D values.
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