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Amyotrophic lateral sclerosis (ALS, OMIM #105400) is a rare and devastating neurodegenerative disorder of unknown etiology characterized by rapidly progressive paralysis leading to death due to respiratory failure, typically within 3 5 years of symptom onset.
Both are fatal within 3 5 years of symptom onset.
Affected subjects die within 2 to 5 years of symptom onset.
Nearly all cases were diagnosed within three years of symptom onset.
It is typically fatal within 2 5 years of symptom onset.
Progressive weakness leads to paralysis that is ultimately fatal, in most cases, within 5 years of symptom onset.
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The drug has a potentially deadly side effect that can occur without warning, after years of symptom-free doses and days after an injection.
In summary, glomerulonephritis can lead to renal failure within a few weeks or months, after many years of symptom-free proteinuria, or after a period of massive proteinuria, which causes the nephrotic syndrome.
In 1994, Jeanne B. Tassis of Prospect, Conn., finally got a diagnosis of lymphedema after almost eight years of symptoms.
Surgeons have used non-degradable synthetic polytetrafluoroethylene (PTFE) or Dacron medium- to large-diameter grafts which provide 10 years of symptom-free lifestyle; however they have extremely poor performance due to thrombotic occlusion and intima hyperplasia when their diameter is <6 mm (Song et al. 2011; Clowes et al. 1985).
Six months of chemotherapy and two years of symptom-free life later, Nienaber's family is glad to have their little slugger back in good health.
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