For example, the Third National Health and Nutrition Examination Survey (NHANES III 1988–1994) study showed that 13% of male and 29% of female adolescents (12 19 years) had deficient levels and that 25% of male and 47% of female adolescents had insufficient levels of 25(OH D during the winter (Looker et al 2002).
In recent years, PrPC-deficient cattle and goats have been produced.
Similarly, among offspring at mean age 9 years, few had deficient (1.3%) or insufficient levels of 25(OH D (21.0%).
In addition, it has been known for many years that leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice have an altered immune response.
Moreover, although the age at diagnosis of patients with MMR-proficient and MMR-deficient tumors was very comparable (67 and 62 years respectively), MMR-deficient tumors carried >55 times more mutations than MMR-proficient tumors.
Those diagnosed at a younger age (<10 years) became insulin-deficient faster than those diagnosed at an older age (≥13 years) (50% insulin deficient by median 18 months [95% CI 13 23] vs. 48 months [37 59]; P < 0.0001).
During the period 3.5 to 1.5 billion years ago, oxygen-deficient environments were prevalent; these favoured the formation of minerals containing ferrous iron (reduced state of iron) from the alteration of basaltic rocks.
Similarly, those diagnosed at a younger age (<10 years) became insulin-deficient faster than those diagnosed at an older age (>13 years).
A few years back, BRCA1/2-deficient cells were shown to be highly sensitive to chemical inhibitors of Poly(ADP-ribose) polymerase-1 (PaRP1), a key molecule in the repair of DNA single-strand breaks (SSBs) (Farmer et al, 2005).
He said the dorm, built 15 years ago, was structurally deficient, but he was reluctant to assign blame.
