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Relative risks were calculated with adjustment for age (5-year classes, 25 70+ years), calendar period (5-year periods, 1990 2000+) and sex.
Stratified analyses were performed by sex, age group (15 39, 40 64, 65 79, or ≥80 years), calendar time period, and immigrants versus Danish residents.
Covariates to be considered in multivariate analysis were selected a priori and included age (completed years), calendar year, and race (white, black, other).
Age at randomisation (under 55, 55 65, over 65 years), calendar period at randomisation (1991 1995, 1996 1999) and FIGO stage (I IV) were successively included in the model.
bAdjusted in multivariate analysis, for age (≥40 versus <40 years), calendar period, HIV-RNA level (≥5 log versus <5), active smoking at cART initiation/resumption, HIV transmission group (homosexual men, heterosexual men, women), geographic origin, time since HIV infection, HIV subtype (B versus non B), baseline genotypic resistance, and CD4 cell count at PHI diagnosis.
Variables were categorised as follows: age at breast cancer diagnosis (⩽50, 51 60, 61 74 years), calendar period at breast cancer diagnosis (1990 1994, 1995 1999, 2000 2006), tumour size (⩽20 mm, >20 mm), lymph node status (positive/negative), ER status (ER-positive/negative) and treatment.
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