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Hence, considering a reasonable time lapse to implement the SPECTRUM solution, the base year of the analysis is set at 2016 for the start of the operational phase.
If market conditions of Murcia are extrapolated to national level the total budgetary impact per patient would be €1.03, €1.37 and €1.58 for the first, second and third year of the analysis.
Since 2008 experienced higher gas prices than other years, it is likely that coal plants were run at higher capacity factors during the first year of the analysis period, potentially leading to trend lines showing a bias towards decreasing coal generation.
As recommended by the "Guide to cost-benefit analysis of investment projects" of the European Commission the analysis will adopt as reference time horizon (years) for SPECTRUM (as a railway project) 30 years.1 Another necessary step is to set the base year of the analysis which often depends on availability of data - preferably as recent as possible.
Given that costs were incurred in the first year of the analysis, costs and outcomes were not discounted.
8 The mean 12-month resource use for PLATO trial patients was used to calculate health state costs in the first year of the analysis.
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The entire year of 2012 was simulated and set as the base year for the analysis of the impacts of the selected measures.
For the analysis, individuals who are not in both years of the analysis are excluded.
This restriction is likely to understate the number of denied applicants slightly, especially for the earlier years of the analysis.
To investigate this we compared regional interval cancer rates in the first and last years of the analysis period.
We noted that even despite older patients entering the cohort in the later years of the analysis, the trend towards better survival was maintained (Additional file 1: Table S3).
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