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One mouse remained alive for almost one year (data not shown).
She developed neonatal hypoglycaemia and was successfully treated by diazoxide during 1 year (data not shown).
Detailed histological examination revealed no abnormality in other tissues from RIP7-rtTA; tet-o-PyMT-IRES-Luc bitransgenic mice that received doxycycline for a year (data not shown).
Extraction success was not obviously related to time of year (data not shown) and was consistently low every year, ranging from 41% (in 2007) to 63% (in 2005).
Importantly, none of the control mice (wild-type for MYC and wild-type or mutant for Rb, n = 12) died from liver cancer within this first year (data not shown).
While there were no differences in body weight when analysing mice up to a life span of one year (data not shown), DMF treatment in YAC128 mice led to a reduction of limb dyskinesia as measured by the clasping score (Fig. 7B).
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Among FV, most patients (n = 75, 32.3%) were in the age category of 45 to 64 years (data not shown).
Most of these patients were elderly [median 71 (IQR 64 76) years (data not shown)], could not drive a car, could not take public transportation, and generally, they did not leave their home.
There was no statistically significant difference in sensitivity to 5FU, paclitaxel, docetaxel, adriamycin and cyclophosphamide between women aged ≤45 years or ≥65 years (data not shown).
Also, the women lost to follow-up were proportionally younger, i.e. of women younger than 44 years of age 83% could be followed (898/1080 = 83%) compared to 88% (3863/4394) of women aged 45-59 years (data not shown).
Depression at baseline was not related to the number of falls (once or more during the follow-up period) nor to the time of falling (first- and/or second-year, data not shown).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com