Sentence examples for ws cells from inspiring English sources

WRN wild type overexpressing WS cells exhibited a significant decrease in sensitivity to etoposide toxicity, compared to WS cells transfected with empty vector.

The aminopyridine CMPD 6r, however, had little effect on WS cells.

These data suggest that MK2 activity plays a substantial role in proliferation control in WS cells.

Thus, we tested the effects of 1 on the lifespan of primary WS cells.

In conclusion we have synthesised two potent and selective JNK inhibitors and tested their effects on the proliferation of WS cells.

Overall the data suggest that total JNK1/2 activity is not involved in the slow growth phenotype of WS cells, or in their aged (stressed) cellular morphology.

These data suggest that total JNK1/2 activity does not play a substantial role in the proliferation control in WS cells.

Previously use of this inhibitor at 2.5 μM had no effect on the growth of telomerised WS cells whereas 10 μM was completely inhibitory [11].

To this end we treated WS and normal fibroblasts with MK2 inhibitors to determine whether MK2 inhibition would affect either the growth or morphology of WS cells.

Although these telomerase-immortalised cells share many of the aged features of primary WS cells [12], they do show different behaviours in certain situations, as exemplified by the differential effects seen with JNK1/2 inhibitors in these cell types [13].

Furthermore, attempts to recover metaphase spreads after Cr VI) exposure of WS cells was unsuccessful, although untreated WS cells did yield metaphase spreads.