Exact(5)
These considerations highlight the need to be very careful when planning control strategies that may result very inefficient for decreasing the systemic risk of infection because of the wrong targeting of outbreak source areas.
Wrong targeting may lead to activation of self-reactive lymphocytes and eventually trigger an autoimmune response, or at least immune responses that consume resources and decrease fitness.
First, wrong targeting can occur if the IS faces pathogens capable of activating the IIS while remaining at abundances too low to be detected by the AIS (i.e., below the efficient presentation threshold a*).
In the light of our previous calculations, the wrong targeting of self-Ags that would lead to bystander activation is very unlikely, although there are two instances where that might occur with higher probability.
Apart from a wrong targeting signal prediction, there is, furthermore, the possibility that some of those proteins are translocated across only the first 2 of the 4 membranes into the periplastidal compartment, present also in C. velia (Moore et al. 2008).
Similar(53)
"But the wrong target".
They were the wrong targets.
You were aiming at the wrong target.
It had picked the wrong target, though.
"But that may be the wrong target".
Sometimes, however, Stewart picked the wrong target.
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Justyna Jupowicz-Kozak
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