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This specificity is important, as activation of the wrong receptor would be very detrimental to the organism (it would be a problem if A + D → Y; Adami 2006).
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It may be that the present vaptans act on the wrong set of receptors in the present clinical scenario.
("In the Smith lab, we've published on the blah-blah receptor"—nothing wrong with that, as long as you add, "I am the lab's expert in the blah-blah technique that forms the core of our assay technology").
From this point of view, flexible docking can decrease the ratio of wrong prediction by considering the conformational change of the receptor during the receptor-ligand binding process.
Thus moving immediately from one endocrine therapy to another in hormone-receptor-positive MBC, may be the wrong strategy in some patients.
Everything you know about where various taste receptors are on your tongue is probably wrong.
It is possible that BPA's binding ERR-γ could affect the receptor's role by activating transcription at the wrong times.
Hetero atoms were removed from the receptors, and then hydrogen atoms were added and wrong valence shells were corrected using Discovery Studio.
In the mice, the overabundance of these receptors led the neurons to make synaptic connections in the wrong places.
Those receptors are made out of proteins that are coded for in DNA, and if the code is off, a medicine designed to fit that receptor may not work as well because the protein may be the wrong shape.
This hypothesis was proven wrong and, surprisingly, basolateral ATP caused a significant, sustained and reversible intracellular alkalization through P2X receptor stimulation in perfused mouse mTALs.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com