It suggests that following either correct or wrong nucleotide incorporation opposite the cross-linked G, further extension might occur at a comparable rate.
Honestly, the most compelling bit from where I stand (directly in front of the mirror, wondering where I've gone wrong) is the incorporation of notifications, serving up weather, calendar alerts, notifications and Spotify playback on the mirror.
For any DNA polymerase, the key question is the relationship of the mechanism to the achievement of fidelity (i.e., discrimination between right (R) and wrong (W) deoxynucleotide incorporation).
Errors secondary to translesion bypass are mechanistically distinct from polymerase replication fidelity, reflecting incorporation of the wrong base opposite a damaged base, versus misincorporation of the wrong base opposite a normal base.
This would prevent the incorporation of the wrong amino acids during translation and the consequent production of cytotoxic misfolded proteins (see fig. 1).
Similar issues exist in biology, for example, protein synthesis that involves assembly of different amino acids is vulnerable to mistakes by erroneous incorporation of a wrong amino acid.
If the product resulting from incorporation of a wrong dNTP had efficiently translocated to the exonuclease active site, the highly active exonuclease should have significantly decreased the accumulation of the mismatched product.
This fidelity is controlled during the start site selection and elongation when the mis-incorporation of the wrong amino acid may alter the integrity of the final product, as well as during termination, when a stop codon might be read through.
For TLS of γ-hydroxypropanodeoxyguanosine by these two polymerases, yeast pol η synthesizes past the adduct relatively accurately, whereas human pol η discriminates poorly between incorporation of correct and wrong nucleotides opposite the adduct (47).
When using attribute AreaEC method siz1 solves all occlusion cases in Figure 3, while straight incorporation of Area would get sequence Figure 3c wrong.
