Different cell types, cytokines, and extracellular matrix molecules at the wound site interact with different systemic factors such as platelets, the coagulation cascade, and humoral cell components, which together enable the healing of wounds [ 2].
Connective tissue cells from different positions around the circumference of the limb stump migrate into the wound site, interact and communicate information about their position of origin, which establishes that there is a positional disparity (i.e. something is missing).
Wounded, wounded, wounded!
We are hopeful that future larger studies will demonstrate the importance of these factors and how they interact with wound closure time.
A new generation of devices, designed to interact with the wound and promote new tissue formation, is currently being developed and tested.
Nonetheless, stem cells use seems beneficial over diffusible factors because stem cells can interact with their wound microenvironment [ 71].
Hemostatic-promoting carriers must (i) circulate in blood without interacting with off target (i.e., nondamaged) endothelium, (ii) marginate to the endothelial wall at the wound site, and (iii) specifically interact with the damaged endothelium and circulating platelets to form a suitable hemostatic plug.
At the end, there are so many factors which may interact to obstruct chronic wounds reepithelialization that it may turn into a puzzle.
Although topical application of a single growth factor is known to accelerate wound healing, treatment with allogeneic cultured cells is more efficient and physiological, because they release various mediators that interact and regulate the wound healing mechanism.
These legible facets of their personality interact with their age and wounds to tell a story.
