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Strikingly, we observed that the functional annotations of these 849 transcripts were significantly enriched in genes involved in immune effector processes (P = 0.006), response to wounding (P = 0.003), cell motility (P = 0.001) and cell adhesion (P = 0.0002) (Figure 2C).
The adherence of Kiss-1 knockdown cells treated with ERK inhibitor significantly decreased compared with that of the control group (no treatment) after wounding (p = 0.0397).
However, in contrast to the hypothesis, the data showed that there was no significant difference in TGF- β1 mRNA levels between WT and GADD34−/− mice after wounding (P > 0.05, Figure 4(a)).
A total of 1317 probes (951 unique genes) showed increased expression in the inflammatory subset (Fig. 3, purple gene cluster) and enrichment in immune system activation (e.g. immune response, p = 2.40*10−11; response to wounding, p = 3.23*10−12; and defense response, p = 4.21*10−07).
A gene ontology (GO) analysis revealed a highly significant decrease in expression of genes encoding proteins involved in signal transduction (p < 0.001) and response to wounding (p < 0.001), mainly affecting genes involved in cytokine-receptor signalling (p < 0.001), chemotaxis (p < 0.001) and inflammatory response (p < 0.001).
Additional enriched categories for the Magenta module include antigen processing and presentation (P = 2.95 × 10-17), positive regulation of response to stimulus (P = 4.30 × 10-17), cell adhesion molecules (P = 1.34 × 10-13), humoral immune response (P = 2.38 × 10-13), response to wounding (P = 5.68 × 10-13), lymphocyte activation (P = 2.93 × 10-11), and cell activation (P = 9.03 × 10-11).
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Table 2 lists a number of enriched biological process categories, including response to wounding (P-value = 6.22 × 10−6) and inflammatory response (P-value = 6.6 × 10−5).
Our data set revealed enriched BP terms for acute inflammatory response (p-value of 3.66 × 10 24) and response to wounding (p-value of 2.14 × 10 22), with 48 and 120 protein identifications, respectively (Supporting Information Figure S-7).
Mayer looked the wounded P-47 over, and then circled to come in from Johnson's six-o'clock to give it the coup de grâce.
The mean systolic pressure was significantly lower in patients with gunshot wounds (p < 0.0001, Table 7).
We found that in the 14 day wounds the keratinocyte area in the Mmp13 Plau double-deficient wounds was significantly larger than in wild-type wounds (p = 0.010) (Figure 3L).
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