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However, clinical cultures have little predictive value of wound outcomes, and culture-independent studies have been limited by cross-sectional design and small cohort size.
In general, immunosuppressive therapy, tissue ischemia, poor wound repair, and other wound characteristics (Table 6) can all present risk factors for poor wound outcomes [45].
Research to integrate the multiple possible wound outcomes into administrative databases is needed to reduce the need for primary data collection for costly follow-up in large scale studies.
However, persistent inflammation or uncontrolled inflammation such as observed in chronic and/or infected wounds results in poor wound outcomes due to delayed wound closure and hypertrophic scarring [ 29].
Briefly, we compared each model built with the original training data against a permuted null distribution containing 1000 iterations with the wound outcomes (healed or dehisced) shuffled randomly among each of the records.
Prospective studies comparing patient and wound outcomes when using culture testing versus molecular microbial testing have not yet been performed, but retrospective studies suggest molecular microbial testing can improve patient outcomes [ 16, 17].
Similar(51)
The aim of this study was to determine the prevalence of protein deficiency in outpatients presenting with leg ulcers and the parameter's prognostic value for wound outcome.
There are several factors that directly impact wound outcome.
We performed univariate analysis to identify general relationships between wound outcome and serum, effluent and gene expression targets.
The association of CCs and the lukDE gene is a powerful tool for predicting the wound outcome.
Statistical differences between these continuous variables and wound outcome were evaluated using the Mann–Whitney U test and the post hoc Tukey Kramer assessment.
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