We know bats can fly with very large holes in their wings (e.g. Davis, 1968), but we don't know if the wounds influence flight performance.
In this model, new PCG expression in muscle at wounds influences (directly or indirectly) the cell types made by neoblasts, promoting regeneration of missing cell types.
Documentation and communication of the size of the wound can influence management, e.g. Gustilo & Anderson classification of open fractures.
How collagen-based wound dressings influence the microbial population in DFUs and biofilm development has not been examined.
A number of other talks underlined that various ECM molecules which are important during wound healing influence cancer malignancy; in turn, cancer cells modulate the expression of ECM molecules in the stroma.
But others in Washington note that while Fannie Mae may be wounded, its influence should not be underestimated.
In the late inflammatory phase, lymphocytes also infiltrate the wound environment influencing fibroblast proliferation and collagen biosynthesis [ 3].
To gain a more dynamic impression of how wounding may influence the behaviour of innate immune cells in the vicinity of cancer cells, we made a series of laser wounds adjacent to clones of pre-neoplastic cells on the flanks of zebrafish larvae (Fig 2A and A') which are amenable to live imaging because of their translucency.
In plants subjected to temperature stress, drought, salinity or mechanical handling, there is an increase in intracellular Ca2+ concentration [ 19], which would promote stimulation of GAD by Ca2+/CaM, whereas exposure to elevated CO2, O2 deficiency and wounding would influence GAD activity by cytosolic acidification in numerous plant tissues and species [ 19, 20].
The study demonstrates the potential for intrinsic defects in inflammatory cells versus a deregulated wound environment to influence wound healing.
