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TGF-β is upregulated following wound infliction and inflammation, and plays an important role in the production of extracellular matrix proteins that contribute to tissue repair.
This work was designed to study the regeneration of lymphatic vessels in rat incisional wounds in relation to the duration after the wound infliction.
Wound infliction was considered as 0 time and wound closure monitored for up to 24 h wound closure.
BM-PC were injected in the tail vein on the day of wound infliction (day 0) and at day 4 post-wounding.
The tensile strength of the incision wound was measured on the seventh day after wound infliction.
As all these pathways are also involved in skin repair, we wanted to investigate if miR-203 contributes to the re-epithelialization process after wound infliction.
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If regeneration-initiation signals were specific to R-wounds, then infliction of H-wounds would not trigger regeneration in dormant tails (Fig. 1, Hypothesis I).
The actus reus is the wound or infliction of grievous bodily harm (GBH).
Wounded, wounded, wounded!
Next, we decided to determine the in vivo effect of Rac1 excision in these animals after the induction of a physiological stress on the epidermis through the infliction of a wound in the dorsal skin.
Remarkably, while only 2% of recessed dormant rays spontaneously resumed regenerative growth in fins that were not re-injured, 52% of rays regenerated upon infliction of skin wounds within 7 d.p.i.
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